Protein Detail

Protein Information

PDBId & Chain	2FNE : A
Molecule	Multiple PDZ domain protein
Residues	95
Sequence
SSE Sequence^*(8)	`EEEHEEHE`

^* Secondary structure Elements (SSE) from N to C terminal of the PDB chain. [SSE: H ("Alpha Helix"); E ("Strands")]

Protein Topology

Topology Information

Protein topology is represented by contact and orientation of secondary structure elements (SSEs). The figure on the left represents the contact map with information on type of orientation two SSEs share (color coded). The matrix can be represented in following string representation.

Contact String
cs [Click here to expand] `0.Ea.Cp.0.Ea.Ca.0-0.0.Ep.0.Cp.0-Ca.Ea.0.0.Ea-0.0.Cp.0-0.Ca.0-0.0-Ea`

Prefence of topology : False

[ Hover over the plot rectangles to know more about SSE-contact ]

Linear Topology Graph : 2FNE_A

Protein Id: 2FNE_A

Figure Detail - Blocks: Helix (rectangles), Strands (triangles); Colormap: Red (N-terminal),--(Green)-- Blue (C-Terminal). Spatial Connectivity by arc Lines [Hover over the image to know the SSE detail]

Topology Graph : 2FNE_A

Protein Id: 2FNE_A

Expand

Figure Detail - Blocks: Helix (circle), Strands (arrow); Colormap: Red (N-terminal), Blue (C-Terminal). Spatial Connectivity by dotted Lines [Hover over the image to know the SSE detail]

Modules in queried Topology

#SSE	SSE string	Contact String	Preferrence	ProteinDB	DomainsDB
3	EEE	0.Ea-0	True	2Y8T:B, 2Y8T:E, 2ZJR:Z, 3H31:A, 3O27:B, 3SF4:D, 3SF4:E, 3SF4:F, 4I6M:D, 4XO1:A, 4YIZ:B, 4YIZ:D, 4YIZ:F, 5DM6:Z, 5ITM:A, 5ITM:B, 5ITM:C, 5ITM:D, 5ITM:E, 5ITM:F, 1AVY:A, 1HLQ:A, 1ICF:I, 1ISU:A, 1PML:A, 2ATC:B, 2DLB:A, 2GGV:A,	d1hlqa_, d1icfi_, d1isua_, d1ppji_, d1rwsa_, d1skza1, d1tdha3, d1yfba1, d2dlba1, d2i9aa2, d2qam01, d2zdra1, d3h31a_, 1avyA00, 1avyB00, 1avyA00, 1avyB00, 1hlqA00, 1icfI00, 1ppjI00, 1rwsA00, 2fd6A02,
3	EEH	Ea.Cp-0	False	5T59:C, 5T59:F, 5TDR:A, 2DS5:A,	d2ds5a_,
3	EEH	Ea.Ca-Cp	True	2ZVX:A, 2ZVX:B, 3BYB:A, 3BYB:B, 3BYB:C, 3FP7:J, 3IUF:A, 3M7Q:B, 3MJH:B, 3MJH:D, 3U1J:E, 3WUP:A, 4BQD:B, 4DTG:K, 4E1P:A, 4E1P:B, 4MPI:A, 4MPI:B, 4NTW:B, 4R2Y:A, 4R2Y:B, 4R2Y:C, 4R2Y:D, 4U30:W, 4U30:X, 4U30:Y, 4U30:Z, 4U32:X, 4UR6:A, 4UR6:B, 4WP4:A, 4WXA:F, 4XKL:D, 4Z0O:A, 5D0I:B, 5I72:A, 5I72:B, 5JB5:A, 5JB5:B, 5JB5:C, 5JG6:A, 5JG6:D, 1AAP:A, 1BUN:B, 1D0D:A, 1DTX:A, 1FAK:I, 1G6X:A, 1HG7:A, 1KTH:A, 1UCS:A, 1Y62:A, 2B9D:A, 2UUY:B, 2VUT:I, 3AUB:A, 5M4V:A,	d1b8ta2, d1bhia_, d1bika1, d1bunb_, d1d0da_, d1dtxa_, d1fu9a_, d1g6xa_, d1jjda_, d1ktha_, d1m36a_, d1neia_, d1njqa_, d1q9ba_, d1srka_, d1tf3a1, d1tf3a3, d1tocr1, d1tocr2, d1u5sb2, d1u85a1, d1ucsa_, d1v6ga2, d1wjpa3, d1x4ka1, d1x61a2, d1x6aa2, d1x6fa1, d1x6ha1, d1x6ha2, d1xbta2, d1yuja_, d2b9da1, d2csha2, d2cu8a2, d2cupa2, d2cuqa1, d2d8xa1, d2dasa1, d2dj7a1, d2djaa1, d2dlka2, d2dloa2, d2dsma1, d2epra1, d2epsa1, d2jz6a1, d2uuyb1, d2vuti1, d2vy4a1, d3m7qb_, 1aapA00, 1bunB00, 1d0dA00, 1aapA00, 1bunB00, 1d0dA00, 1dtxA00, 1g6xA00, 1gjzA00, 1jjdA00, 1kthA00, 1neiA00, 1ucsA00, 2vutI00,
4	HEEH	0.Ea.Ca-0.Cp-0	True	2YNY:A, 2YNY:C, 3UK3:C, 3UK3:D, 4BMJ:F, 4BMJ:G, 4F52:B, 4ISO:B, 5MQ4:B, 5MQ4:C, 5MQ4:D, 5MQ4:E, 5MQ4:F, 1ZR0:B,	d1vlia1, 1yuiA00,
4	EEHE	Ea.Ca.0-Cp.0-Ea	True	2YVR:A, 2YVR:B, 3DDT:B, 3DDT:C, 3Q1D:A, 5K3Q:A, 5K3Q:B, 5K3Q:C, 5K3Q:D, 5TDA:A, 5TDC:A, 1LDT:L,	d1ldtl_, d2dida1, 1ldtL00,

Protein In ProLegoDB with identical/similar Topology

Proteins with Identical Topology

[Same secondary structure composition, contact-pair and orientation]

PDB Id	Chain	Residues	Molecule	Detail Topology

Protein with similar Topology [same scaffold]

[Same secondary structure composition and contact-pair but of different orientation]

PDB Id	Chain	Residues	Molecule	Detail Topology
3AXA	A	97	Afadin	View
3AXA	B	97	Afadin	View
3PS4	A	96	Microtubule-associated serine/threonine-protein kinase 1	View
5GLJ	D	96	Tyrosine-protein phosphatase non-receptor type 13	View
2JIK	A	101	Synaptojanin-2-binding protein	View

Proteins with topologies of same secondary structure (H/E) component

[Topologies with same secondary structure composition with different contact-pairs and orientation]

PDB Id	Chain	Residues	Molecule	Detail Topology
2Z17	A	94	Cytohesin-interacting protein	View
3B76	A	101	E3 ubiquitin-protein ligase LNX	View
3GGE	A	95	PDZ domain-containing protein GIPC2	View
3GGE	C	95	PDZ domain-containing protein GIPC2	View
3KHF	A	96	Microtubule-associated serine/threonine-protein kinase 3	View
3KHF	B	97	Microtubule-associated serine/threonine-protein kinase 3	View
3KZD	A	85	T-lymphoma invasion and metastasis-inducing protein 1	View
3LNY	A	94	Tyrosine-protein phosphatase non-receptor type 13	View
3NFK	A	92	Tyrosine-protein phosphatase non-receptor type 4	View
3NFK	B	91	Tyrosine-protein phosphatase non-receptor type 4	View
3O46	A	83	MAGUK p55 subfamily member 7	View
3O5N	C	97	SH3 and multiple ankyrin repeat domains protein 3	View
3O5N	D	100	SH3 and multiple ankyrin repeat domains protein 3	View
3O5N	E	92	SH3 and multiple ankyrin repeat domains protein 3	View
3O5N	F	97	SH3 and multiple ankyrin repeat domains protein 3	View
3O5N	G	95	SH3 and multiple ankyrin repeat domains protein 3	View
3PS4	B	97	Microtubule-associated serine/threonine-protein kinase 1	View
3PS4	C	96	Microtubule-associated serine/threonine-protein kinase 1	View
3PS4	D	99	Microtubule-associated serine/threonine-protein kinase 1	View
3R5L	A	114	Deazaflavin-dependent nitroreductase	View
3R68	A	85	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	View
3RL7	A	90	Disks large homolog 1	View
3RL7	B	89	Disks large homolog 1	View
3RL7	C	87	Disks large homolog 1	View
3RL7	D	92	Disks large homolog 1	View
3RL7	E	82	Disks large homolog 1	View
3RL7	F	91	Disks large homolog 1	View
3VQF	A	85	E3 ubiquitin-protein ligase LNX	View
4H11	A	102	Disks large homolog 2	View
4H11	B	102	Disks large homolog 2	View
4N6X	A	91	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	View
4P0C	A	88	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	View
4Q2N	A	93	InaD-like protein	View
4Q2N	B	99	InaD-like protein	View
4Q2N	C	90	InaD-like protein	View
4Q2N	D	95	InaD-like protein	View
4Q2N	E	97	InaD-like protein	View
4Q2N	F	98	InaD-like protein	View
4Q2P	B	87	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	View
4Q2P	C	80	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	View
4Q2Q	A	90	Tight junction protein ZO-1	View
4Q3H	A	90	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	View
4Q3H	B	90	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	View
4R2Z	A	84	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	View
4R2Z	B	81	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	View
4UU5	A	90	MAGUK p55 subfamily member 5	View
4YDP	A	83	LIM domain-binding protein 3	View
4YDP	B	83	LIM domain-binding protein 3	View
5E1Y	A	95	Ligand of Numb protein X 2	View
5GLJ	A	96	Tyrosine-protein phosphatase non-receptor type 13	View
5GLJ	B	93	Tyrosine-protein phosphatase non-receptor type 13	View
5GLJ	C	94	Tyrosine-protein phosphatase non-receptor type 13	View
5I7Z	A	96	Par-6, isoform B	View
5TYT	A	89	Rho guanine nucleotide exchange factor 11	View
5TYT	B	89	Rho guanine nucleotide exchange factor 11	View
5TYT	C	87	Rho guanine nucleotide exchange factor 11	View
5TYT	D	89	Rho guanine nucleotide exchange factor 11	View
1IHJ	A	94	Inactivation-no-after-potential D protein	View
1KWA	A	88	Peripheral plasma membrane protein CASK	View
1N7E	A	95	Glutamate receptor-interacting protein 1	View
1O51	A	86	UPF0166 protein TM_0021	View
1Q3O	A	104	SH3 and multiple ankyrin repeat domains protein 1	View
1QAV	A	90	Alpha-1-syntrophin	View
1R6J	A	82	Syntenin-1	View
2AWX	A	92	Disks large homolog 1	View
2BYG	A	98	Disks large homolog 2	View
2DCL	A	99	UPF0166 protein PH1503	View
2EAQ	A	89	LIM domain only protein 7	View
2EGO	A	88	General receptor for phosphoinositides 1-associated scaffold protein	View
2F0A	A	87	Segment polarity protein dishevelled homolog DVL-2	View
2F5Y	A	82	Regulator of G-protein signaling 3	View
2FCF	A	89	Multiple PDZ domain protein	View
2FE5	A	94	Disks large homolog 3	View
2GZV	A	91	PRKCA-binding protein	View
2HE4	A	90	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	View
2HW4	A	116	14 kDa phosphohistidine phosphatase	View
2I04	A	85	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	View
2I1N	A	101	Disks large homolog 3	View
2IWN	A	93	Multiple PDZ domain protein	View
2IWO	A	92	Multiple PDZ domain protein	View
2JIL	A	95	Glutamate receptor-interacting protein 1	View
2OPG	A	98	Multiple PDZ domain protein	View
2PA1	A	87	PDZ and LIM domain protein 2	View
2PKT	A	91	PDZ and LIM domain protein 1	View
2Q3G	A	89	PDZ and LIM domain protein 7	View
2Q9V	A	90	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	View
2QG1	A	89	Multiple PDZ domain protein	View
2QKV	A	92	Inactivation-no-after-potential D protein	View
2R4H	A	90	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	View
2UZC	A	87	PDZ and LIM domain protein 5	View
2V1W	A	89	PDZ and LIM domain protein 4	View
2V90	A	95	Na(+)/H(+) exchange regulatory cofactor NHE-RF4	View
2VRF	A	95	Beta-2-syntrophin	View
2W4F	A	95	Protein scribble homolog	View
4JOK	A	87	Golgi-associated PDZ and coiled-coil motif-containing protein	View

Topology view of query protein [ProLego results]

2FNE : A

Topology Information