ProLego Protein as lego blocks ...
 

Topology Browser  [Search with followings]

Structure class: [A: Alpha (all helix); B: Beta (all strands); AB: alpha-beta (mixed)]

SS composition: [SSE: Secondary structue from N to C terminal of protein chain]

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# Helix: [Number con alpha helix in protein chain]

# Strands: [Number of beta strands in protein chain]

Minimum number of SSE contact pair: [Least number of Secondary structure pairwise contacts]

Topology preferance status: [True/False Preferred topologies are most frequently occurred scaffolds in a SSE composition]

(search in combination or with any one input)

 
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Topology List   [Click on a Topology String to explore]

Str Class Sse String H E Topology String Paired Contacts Is Preferred topoGrp statSig
AB EHE 1 2 Topology 1 ✔ False
A HHH 3 0 Topology 1 ✔ True
A HHH 3 0 Topology 1 ✘ True
A HHH 3 0 Topology 1 ✘ True
AB EHHE 2 2 Topology 1 ✘ False
A HHHH 4 0 Topology 1 ✘ True
A HHHH 4 0 Topology 1 ✘ True
A HHHH 4 0 Topology 2 ✔ True
A HHHH 4 0 Topology 1 ✔ True
AB EHEH 2 2 Topology 1 ✔ False
AB EHEE 1 3 Topology 2 ✘ True
B EEEE 0 4 Topology 2 ✘ True
AB EHEH 2 2 Topology 2 ✘ False
A HHHH 4 0 Topology 1 ✘ True
A HHHH 4 0 Topology 1 ✘ True
A HHHH 4 0 Topology 1 ✘ True
A HHHH 4 0 Topology 2 ✘ True
A HHHH 4 0 Topology 3 ✘ True
AB HHEHE 3 2 Topology 1 ✘ False
A HHHHH 5 0 Topology 2 ✘ True
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Table Description [Click here to expand]

Above table lists all the available topologies in the ProLego database. Each topology (row in the table), refers to a possible contact combination of secondary structure elements (SSEs). The table column headers can be read as following,

  • topClass:  Structure Class [A: All alpha; B: all Beta, AB: alpha beta Mix]
  • Helix (H):  Number of helices in structure.
  • Strands (E):  Number of beta-strands in structure.
  • SSE string:  SSE string represents the occurences of Heleix(H) and Beta-Strands(E) in sequce from N to C terminal.
  • Paired Contact:  Number of pair-wise contact in a topology [varies from 1 to n*(n-1)/2 ; where n is number of secondary structures (H and E)]
  • Topology String:  The link for vizualising and detail information on a particular topology
  • Is Preferred:  Prefernce of a Topology in the group of SSE
  • topoGrp statSig:  Statistical significance of a topology class